Think tank · Policy · Covent Garden, London · Est. 2019
The Centre for Long-Term Resilience (CLTR) is an independent, non-partisan UK think tank focused on policy and governance for extreme risks, especially advanced AI risk, biosecurity, and government risk management. CLTR’s stated mission is to “transform global resilience to extreme risks” in the UK and internationally, and it describes its methods as producing actionable policy advice and red-teaming, convening cross-sector conversations/workshops, and facilitating specialist knowledge exchange (including expert placements into government).
On the organizational side, CLTR is registered as a non-profit company limited by guarantee under the name Alpenglow Group Limited (company number 12308171).
New research published today by the Loss of Control Observatory shows that AI loss of control incidents are worsening significantly.
Progress on Biosecurity in the European Biotech ActCLTR responds to the amendments tabled by the joint SANT and ITRE committees and to the ENVI and JURI opinions.
Report: CLTR finds a 5x increase in scheming-related AI incidentsThe Loss of Control Observatory analysed over 183,000 AI interaction transcripts and found a 5x increase in scheming-related incidents over five months.
Ten things we want to see from Exercise PegasusWhat does best-in-class risk preparedness exercising look like? We outline ten key benchmarks we'll be watching for from Exercise Pegasus to demonstrate the UK is operating at that level.
Informing the European Biotech Act and Inclusions of our RecommendationsIn November 2025, we submitted written evidence to the European Union (EU)’s Public Consultation informing the European Biotech Act.
How the UK Government can govern the risk of loss of controlThe UK Government is beginning to express significantly more concern about the risk that increasingly autonomous AI systems might at some point evade human oversight and control.
The Loss of Control Observatory: a prototype to detect real-world AI control incidentsCLTR is developing a new methodology to systematically detect and analyse concerning autonomous behaviours, as part of a broader programme of work on loss of control
Defensive acceleration: the strategic pivot needed for UK biological resilienceA framework and four priority programmes to grow the economy and strengthen UK biosecurity in the age of AI.
Gap consolidation of the mirror life evidence baseWe have identified specific, safe knowledge gaps to fill for preparedness without lowering the barriers to creating mirror life.
Cost-Benefit Analysis of Synthetic Nucleic Acid Screening for the UKWe found that mandatory screening synthetic nucleic acids over 50 base pairs in length bought or sold in the UK would be highly cost-beneficial.
Advancing The Uks Global Leadership In Frontier Ai GovernanceSimulations Suggest That Antibiotics Would Not Work On Mirror Bacterial TargetsCLTR reported findings from its Loss of Control Observatory, including claims about worsening severity of loss-of-control incidents and calls for UK government mandates on monitoring/reporting and emergency powers.
Progress on Biosecurity in the European Biotech ActCLTR published updates responding to developments related to the European Biotech Act, describing how CLTR’s biosecurity policy work relates to EU legislative changes.
Response to the Defence Investment PlanCLTR published a response to the UK Government’s Defence Investment Plan, including CLTR’s framing of AI as a defining security challenge and its specific comments in that response.
Report: CLTR finds a 5x increase in scheming-related AI incidentsCLTR published a report based on analysis of transcripts from deployed AI systems shared on X, describing findings about increased scheming-related incidents and launching its Loss of Control Observatory (as described by CLTR).
Ten things we want to see from Exercise PegasusCLTR published guidance listing benchmarks it says it will watch for from Exercise Pegasus as a measure of preparedness exercise quality.
Informing the European Biotech Act and Inclusions of our RecommendationsCLTR described its submission of written evidence to an EU public consultation and framed this as informing the European Biotech Act’s approach and inclusions of its recommendations.