Think tank · Policy · Eye Street NW, Suite · Est. 2001
The Nuclear Threat Initiative (NTI) is a nonprofit, nonpartisan global security organization focused on reducing nuclear, biological, and emerging technology threats that imperil humanity. NTI combines policy analysis and convening with targeted program implementation to help governments and partners reduce catastrophic risks—spanning nuclear security and strategic stability, biosecurity and the governance of AI-enabled life science tools, and practical risk-reduction initiatives that aim to strengthen safeguards and reduce the likelihood of accidental, mistaken, or unauthorized use or escalation.
As of late 2025, NTI transitioned leadership with Christine E. Wormuth taking over as President and CEO (effective November 17, 2025), following Ernest J. Moniz’s tenure as CEO and co-chair. NTI’s public communications and program descriptions emphasize (1) nuclear risk reduction through fail-safe and stability-focused work, (2) biosecurity governance and safeguards around advanced biological capabilities—especially where AI and life sciences converge—and (3) emerging-technology risk mitigation through concrete tools, frameworks, and policy engagement. Institutionally, NTI is positioned as a long-running convenor and implementer in WMD risk reduction, with programs that explicitly connect policy output to real-world operational steps—such as supporting mechanisms for DNA screening of synthesis orders and publishing policy frameworks for how biological AI tools could be governed to reduce misuse risk.
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NTI announced results from YouGov polling commissioned by NTI and ReThink Media on public support for U.S.-China cooperation to mitigate catastrophic threats associated with nuclear risks, AI development, and bioterrorism.
Russia and United States Retreat from Nuclear Security as 12 Countries Step Up, 2026 NTI Nuclear Security Index FindsNTI released the 2026 Nuclear Security Index, reporting an overall decline in nuclear security conditions for Russia and the United States and improvement for 12 other countries, and presenting the Index’s key drivers.
NTI Engages Senior Congressional Staff with New Congressional Leadership Project (CLP)NTI reported that the inaugural edition of its Congressional Leadership Project concluded, describing the program’s structure, topics, and participant feedback, and noting an application process for a second cohort.
New NTI Framework Tackles Misuse Risks in AIxBio ToolsNTI announced a policy framework describing managed access for biological AI tools to reduce misuse risk, based on interviews with biosecurity and AIxBio experts, and invited tool developers and stakeholders to adopt the approach.
NTI Welcomes Christine E. Wormuth as President and CEONTI announced that Christine E. Wormuth would join as President and CEO effective November 17, 2025, following Moniz’s departure from the CEO role.
NTI Launches Scoping Effort for AI-Bio ForumNTI reported that NTI | bio convened experts in January 2024 to outline steps toward establishing an international AI-Bio Forum, and described the next steps for scoping the forum’s structure and participants.